Vitamin D Research: The Potential is Great
What is Vitamin D?
Vitamin D is the fat-soluble precursor of the steroid hormone, Calcitriol. Among other functions, it is necessary for calcium homeostasis and mineralisation within bone tissue. This vitamin becomes active in the body once modified to either:
A low blood level of 25-hydroxyvitamin D indicates a lack of sunlight exposure or low dietary intake. High levels of Vitamin D indicate an excess of parathyroid hormone (PTH), the hormone responsible for activating it.
What is Calcium?
Calcium is the most abundant mineral in the body. Calcium ions (Ca2+) are involved in a multitude of physiological processes. Serum concentrations are controlled by:
- Parathyroid hormone (PTH) which stimulates calcium release from bone
- Vitamin D which causes increased absorption of calcium by the intestines.
Why is Vitamin D Important?
Vitamin D is essential for bone health and metabolism of minerals. Research has illustrated its vital role in child development in utero.
The expression of hundreds of genes is regulated by 1,25-Dihydroxyvitamin D3 (Calcitriol). Calcitriol also triggers signalling cascades in tissues throughout the body. Lack of 1,25-Dihydroxy Vitamin D3 leads to kidney disease and is indicative of the early stages of kidney failure. Lack of Vitamin D leads to rickets in children and osteomalacia in adults. It contributes to osteoporosis, hyperparathyroidism, muscle weakness and myalgia/pain. Prolonged Vitamin D deficiency causes an increased risk of many chronic conditions: anaemia, cognitive disorders and depression, cardiometabolic and autoimmune diseases, sleep disorders, neurodegenerative conditions and it has been linked to some cancers.
A complete Vitamin D assay can be performed to measure its active forms. Vitamin D screening is indicated for all high risk individuals, e.g. osteoporosis, patients with rickets/osteomalacia, chronic kidney disease and malabsorption syndrome.
Alongside existing applications, the latest research has revealed that Vitamin D plays a crucial role in the treatment of fibromyalgia due to its ability to switch genes on and off.
Biorbyt can help you with your Vitamin D research
Research indicates the potential for Vitamin D to play a role in the treatment of diseases such as autism, cancer, heart disease, diabetes, and periodontal disease among others.
Along with our wide range of antibodies and testing tools, we have what you need to perform and advance your Vitamin D experimentations. See below for a selection of our antibodies to help with your research today.