TRIM

SKU: orb1306819

Description

TRIM (1-(2-Trifluoromethylphenyl)imidazole) is a selective neuronal nitric oxide synthase (nNOS) inhibitor. It is a valuable research tool for investigating the role of nNOS in neurological functions and disorders, applicable in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 25371-96-4
• MW: 212.17
• Purity: 99.51% (May vary between batches)
• Formula: C₁₀H₇F₃N₂
• SMILES: FC(F)(F)C1=C(C=CC=C1)N1C=CN=C1
• Target: NOS,NO Synthase
• Solubility: DMSO:2.13 mg/mL (10.04 mM)

Bioactivity

• In Vivo:
  TRIM is a poor inhibitor of bovine aortic endothelial NOS with an IC50 of 1057.5 microM. TRIM (10-50 mg kg-1) administered i.p. exhibits dose-related antinociceptive activity in the mouse (assessed as inhibition of late phase formalin-induced hindpaw licking behaviour) with an ED50 of 85.8 mumol kg-1. In contrast, TRIM (50 mg kg-1, i.p.) failed to influence mean arterial blood pressure in the urethane-anaesthetized mouse.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anxiolytic-like effects, antidepressant, 1-(2-Trifluoromethylphenyl)imidazole, inhibit, NOS, Nitric oxide synthases, NO Synthase, nNOS, eNOS, iNOS, Inhibitor, TRIM

Compound Identifiers

PubChem CID

1359