Toll-Like Receptor 3 Antibody

• Catalog Number: orb1732714
• Category: Antibodies
• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 2H5
• Tested applications: WB
• Isotype: Mouse IgG2b
• Immunogen: Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.
• Concentration: 1mg/ml
• Dilution range: WB: 1/500-1/1000
• Conjugation: Unconjugated
• MW: Calculated MW: 104 kDa; Observed MW: Refer to figures
• Entrez: 7098
• UniProt ID: O15455
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUM
• Note: For research use only
• Expiration Date: 12 months from date of receipt.