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Oncology & Inflammation
Tumor Necrosis Factor Alpha (TNF-α) plays a dual role in cancer, capable of both promoting tumour growth and inducing cell death, depending on the tumour context.
As a key inflammatory mediator, TNF-α is involved in a wide range of biological processes including immune responses, cell differentiation, and tumour cell apoptosis. Its involvement in autoimmune diseases and cancer progression underscores its importance in therapeutic research. Understanding TNF-α’s mechanisms is crucial for developing targeted cancer therapies and immunotherapies.
Signaling cascades initiated by Tumor Necrosis Factor Alpha.
TNF-α can kill or slow the growth of some tumour cells, though its effects vary across different cell types. For example, combining TNF-α with chemotherapy agents like dactinomycin can increase its tumor-killing effects. However, tumours in living organisms may resist TNF-α, sometimes due to high levels of endogenous TNF-α or other resistance mechanisms. Macrophages, with TNF-α on their surface, also contribute to targeting cancer cells.
TNF-α is also a crucial component of the immune system’s response to infections, particularly viral infections. It helps destroy virus-infected cells by boosting neutrophil activity and inhibits the replication of viruses such as influenza. Furthermore, TNF-α plays a role in generating fever as a part of the body’s defence mechanism against infections.
TNF-α is central to regulating the immune system. It’s involved in various autoimmune diseases, including lupus and Sjögren’s syndrome, where its levels are often elevated. By influencing immune cells, TNF-α can drive both immune activation and immune suppression, which is critical for understanding its role in cancer and autoimmune diseases.
Biorbyt offers highly validated primary antibodies and recombinant proteins for studying TNF-α expression and signaling dynamics in vitro and in vivo.
| Product ID | Description |
|---|---|
| orb371962 | TNF alpha antibodyPrimary Antibody |
| orb705324 | Recombinant Human TNF proteinRecombinant Protein |
| orb323199 | Anti-TNF alpha AntibodyPrimary Antibody |
| orb1516920 | Recombinant mouse TNF-Alpha protein, N-HisRecombinant Protein |
Beyond oncology, TNF-α is a master regulator of systemic inflammatory processes, playing critical roles in metabolic disorders, pathogen defense, and acute systemic responses.
Excessive TNF-α production due to bacterial infections can lead to septic shock, causing widespread inflammation, organ failure, and high mortality. It also contributes to liver damage during viral infections, like hepatitis.
TNF-α, sometimes called cachectin, is associated with cachexia, a syndrome of weight loss and muscle wasting commonly seen in cancer patients. It contributes to metabolic changes that result in severe physical decline, especially in advanced stages.
TNF-α has antiviral properties similar to interferon (IFN). In HIV-infected T cells, TNF-α can activate the NF-κB pathway, which is crucial for HIV gene expression and viral replication. It also exhibits antibacterial and antimalarial effects.
Accurately quantify TNF-α levels in serum, plasma, and cell culture supernatants with our highly sensitive, species-specific ELISA kits.
| Product | Description / Application |
|---|---|
| Human ADAM17 ELISA Kit | Ideal for analyzing the role of ADAM17 in inflammation and cancer. |
| Human anti-TNF-α Antibody ELISA Kit | Specifically designed for the detection of anti-TNF-α antibodies in therapeutic research. |
| Mouse TNF-α ELISA Kit | Perfect for highly sensitive measurements of TNF-α in mouse models. |
| Human HS-TNF-α (High Sensitive) ELISA Kit | Provides high sensitivity for detecting low TNF-α levels in human samples. |
| Human TNF-α ELISA Kit | For quantifying baseline and elevated TNF-α levels in human blood and tissue samples. |
| Rat TNF-α ELISA Kit | Designed for TNF-α measurement in rat models, aiding research into inflammation and disease mechanisms. |
| Mouse TNF-α ELISA Kit | Suitable for standard assessments of TNF-α levels in mouse cancer models. |
