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TASK1 Potassium Channel antibody (APC)

Catalog Number: orb151064

Product Overview
Product Name TASK1 Potassium Channel antibody (APC)
Catalog Number orb151064
Species/HostMouse
ReactivityRat
ConjugationAPC
Tested applicationsICC, IF, IHC-P, WB
Immunogen Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (accession no. O54912) Mouse: 96% identity (156/161 amino acids identical) Human: 76% identity (163/161 amino acids identical) <30% i
Target TASK1 Potassium Channel. Detects a 50 kDa protein. Does not cross-react with TASK3.
Product Properties
Form/Appearance PBS pH 7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Storage Store at 2-8°C and -20°C for one year. (Shipped on ice packs)
Note For research use only.
Isotype IgG2b
ClonalityMonoclonal
Purity Protein G Purified
MW 50 kDa
Clone ID S374-48
Uniprot ID O54912
Product Description

Mouse monoclonal to TASK1 Potassium Channel (APC). K+ channels are divided into three subclasses reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions and include TWIK, TREK, TRAAK and TASK. TASK channels are highly sensitive to external pH in the physiological range. TASK-1 is expressed in brain and in rat heart, with high levels of expression in the right atrium. TASK-2, mainly expressed in kidney, is localized in cortical distal tubules and collecting ducts, suggesting a role in renal K+ transport. TASK-3 from rat cerebellum shares 54% identity with TASK-1, but less than 30% identity with TASK-2 and other tandem pore K+ channels..

Application Notes
Dilution Range WB:1:100
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