SUR1 antibody

• Catalog Number: orb149970
• Category: Antibodies
• Description: Mouse monoclonal to SUR1 (ATTO-390). Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6. x (6. 1 and 6. 2). The association of four Kir6. x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6. x potassium channel. Hence the KATP channel monitors the energy balance within the cell..
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: S289-16
• Tested applications: ICC, IHC, WB
• Reactivity: Hamster, Human, Mouse, Rat
• Isotype: IgG1
• Immunogen: Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
• Concentration: 1 mg/ml
• Dilution range: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
• Conjugation: ATTO-390
• MW: 160kDa
• Target: SUR1
• Entrez: 25559
• UniProt ID: Q09429
• NCBI: NP_037171.2
• Storage: Conjugated antibodies should be stored at 4°C
• Buffer/Preservatives: PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
• Alternative names: AM60008PU-N antibody, ABC36 antibody, Abcc8 antibo
• Note: For research use only
• Application notes: 1 µg/ml of SMC-409 was sufficient for detection of SUR1 in 20 µg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
• Expiration Date: 12 months from date of receipt.