Stavudine

SKU: orb1308721

Description

Stavudine (BMY-27857) is a thymidine-analog nucleoside reverse transcriptase inhibitor (NRTI) active against HIV-1. It has been widely used in antiretroviral research, with established applications in both in vitro antiviral assays and in vivo models of HIV infection.

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 3056-17-5
• MW: 224.2
• Purity: 98.91% (May vary between batches)
• Formula: C₁₀H₁₂N₂O₄
• SMILES: CC1=CN(C2OC(CO)C=C2)C(=O)NC1=O
• Target: Inflammasome
• Solubility: Soluble in DMSO (up to 20 mg/ml), or in Water (up to 20 mg/ml).

Bioactivity

• In Vivo:
  Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM).
• In Vitro:
  In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMY 27857; d4T

Compound Identifiers

PubChem CID

5155