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Product Overview
Product Name SOX2 antibody
Catalog Number orb178730
Species/HostRabbit
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
Tested applicationsIHC-P, WB
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human SOX2, different from the related mouse and rat sequence by one amino acid.
Target SOX2. Human, Mouse, Rat. No cross reactivity with other proteins.
Alternative Names
Product Properties
Form/Appearance Lyophilized, Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Storage Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Note For research use only.
Reconstitution Add 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Isotype Rabbit IgG
ClonalityPolyclonal
Purity Immunogen affinity purified.
Uniprot ID P48431
Product Description

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency of undifferentiated embryonic stem cells. Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This gene is mapped to 3q26.33. It is found that SOX2 can regulate OCT3/4 expression and maintains ES pluripotency through upstream transcription factors. SOX2 is identified as a lineage-survival oncogene in lung and esophageal squamous cell carcinoma. In addition to those, SOX2 has a critical role in maintenance of embryonic and neural stem cells and holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.

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