SKLB 1028

SKU: orb1695203

Description

SKLB 1028 (Ruserontinib) is an oral multikinase inhibitor targeting EGFR, FLT3, and Abl kinases. It demonstrates potent efficacy in FLT3-driven acute myeloid leukemia (AML) models in vitro and in vivo, and shows significant activity against chronic myeloid leukemia (CML) models harboring Abl mutations.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1350544-93-2
• MW: 443.55
• Purity: >99.99% (May vary between batches)
• Formula: C₂₄H₂₉N₉
• SMILES: C(C)(C)N1C=2C(N=C1NC=3C=CC=NC3)=CN=C(NC4=CC=C(C=C4)N5CCN(C)CC5)N2
• Target: Bcr-Abl,EGFR,FLT
• Solubility: DMSO:50 mg/mL (112.73 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BcrAbl, Abl, EGFR, FLT3, SKLB1028, SKLB-1028, SKLB 1028, Ruserontinib

Compound Identifiers

PubChem CID

54760385