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Product Overview
Product Name Sheep Leptin tA (PEG) protein
Catalog Number orb426848
ReactivitySheep
ConjugationUnconjugated
Target Leptin tA (PEG)
Product Properties
Form/Appearance White lyophilized (freeze-dried) powder.
The protein was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3.
Storage Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Note For research use only.
Purity >95.0% as determined by: (a) Gel filtration analysis. (b) Analysis by SDS-PAGE.
Source Escherichia coli.
Activity Pegylated triple antagonist is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Its in vitro activity is 6-8 fold lower than the non-pegylated antagonist but in vivo it has profound weight gain effect (as compared to the non-pegylated antagonist like in mouse leptin antagonists), resulting mainly from increased food intake.
Product Description

Recombinant of sheep Leptin tA (PEG) protein

Solubility (25°C)
Solubility (25°C) It is recommended to reconstitute the lyophilized Leptin-Antagonist Triple Mutant Ovine Recombinant in sterile water or sterile 0.4% NaHCO3 adjusted to pH 8, not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
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