SHBG141€"161 peptide

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Product Name SHBG141€"161 peptide
Catalog Number orb1147041
Hazard Information Non-Toxic
Alternative Names
Storage Store dry, frozen and in the dark
Note For research use only.
Protein Sequence H-Ile-Ala-Leu-Gly-Gly-Leu-Leu-Phe-Pro-Ala-Ser-Asn-Leu-Arg-Leu-Pro-Leu-Val-Pro-Ala-Leu-OH
Purity > 95% by HPCL
Formula C103H173N25O24
MW 2145.66
Activity GPRC6A agonist
Solubility (25°C) Soluble in water
Description SHBG141–161 is a peptide corresponding to amino acids 141–161 of sex hormone binding globulin (SHBG), the loop region of SHBG connecting β-strands 11 and 12. SHBG141–161 is an agonist of the class C orphan G protein coupled receptor GPRC6A, a major regulator of energy metabolism and male fertility, and SHBG141-161 competes for binding to it with its endogenous ligand undercarboxylated osteocalcin (ucOCN). In vitro, SHBG141-161 stimulates insulin secretion from β-cells and also the production and release of testosterone from Leydig and Langerhans β-cells cell lines.
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