SCH-58261

SKU: orb1226068

Description

SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively; displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively; reverses reperfusion injury (IR) increased hippocampal Glu, GABA, glycine and aspartate, MPO, TNF-α, nitric oxide, and PGE in Male Wistar rats.

Key Properties

• CAS Number: 160098-96-4
• MW: 345.358
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₅N₇O
• SMILES: NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14
• Target: Adenosine Receptor
• Solubility: DMSO: ≥ 34 mg/mL

Bioactivity

• In Vivo:
  Animal model: 4 6 weeks old athymic nude mice (NCI) with PC9 cells xenograft. Dosage: 2 mg/kg. Administration: Intraperitoneal injection; daily; for 20 days. Result: Decreased tumor growth.
• In Vitro:
  Cell Viability Assay Cell line: H1975 cells. Concentration: 10 nM-10 μM. Incubation time: 7 days. Result: Produced a concentration-dependent decrease in H1975 cell growth. Cell Proliferation Assay Cell line: CAF cells. Concentration: 25 μM. Incubation time: 72 hours. Result: Inhibit the growth of CAF1 and CAF2 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCH 58261 | SCH58261

Quick Database Links

Gene Symbol

Adenosine Receptor