SCH-58261 is a potent and selective, competitive A2A adenosine receptor antagonist with Ki of 2.3 nM and 2.0 nM in rat and bovine brain, respectively; displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively; reverses reperfusion injury (IR) increased hippocampal Glu, GABA, glycine and aspartate, MPO, TNF-α, nitric oxide, and PGE in Male Wistar rats.