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SBSN Antibody / Suprabasin
Catalog Number: orb1824719
| Catalog Number | orb1824719 |
|---|---|
| Category | Antibodies |
| Description | Suprabasin (SBSN) is a 247 amino acid secreted protein that is upregulated in differentiating keratinocytes and is though to play a role in epidermal differentiation. Expressed in uterus, skin, thymus and esophagus, suprabasin is encoded by a gene that maps to human chromosome 19q13.12. Chromosome 19 consists of about 63 million bases with over 1,400 genes, making up over 2% of human genomic DNA. Chromosome 19 is the genetic home for a number of immunoglobulin superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families, and Fca receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and Insulin-dependent diabetes have been linked to chromosome 19. |
| Species/Host | Mouse |
| Clonality | Monoclonal |
| Clone Number | SBSN/7961 |
| Tested applications | IHC-P |
| Reactivity | Human |
| Isotype | Mouse IgG1, kappa |
| Immunogen | A recombinant fragment from the human protein was used as the immunogen for the SBSN antibody. |
| Antibody Type | Primary Antibody |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Conjugation | Unconjugated |
| Formula | 1 mg/ml in 1X PBS; BSA free, sodium azide free |
| Hazard Information | This SBSN antibody is available for research use only. |
| UniProt ID | Q6UWP8 |
| Storage | Aliquot the SBSN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human esophagus tissue with SBSN antibody (clone SBSN/7961). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free SBSN antibody (clone SBSN/7961) as confirmation of integrity and purity.
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