Rat Monoclonals - A great alternative to Mouse

An introduction to rat monoclonals

Have you ever considered using rat monoclonal antibodies (mAbs) for your research? We know that high quality antibodies are vital to allow you to have confidence in your data. High quality monoclonal antibodies will make the difference between failure and success. Biorbyt is able to offer high affinity and high specificity monoclonal antibodies raised in a wide range of species, including rat. Our rat monoclonals are an excellent choice, especially for detection or purification of poor immunogenic compounds and molecules of low molecular weight. In many cases, rat mAbs are preferable to mouse. Rat mAbs can be used alone or in combination with other species to increase your experimental options. Whatever field of research, Medicine, Biochemistry, Biology, Molecular Biology, if you are looking to purify, diagnose or detect, and for single or multiple labelling, rat monoclonals are definitely worth considering.

Immunohistochemical staining of paraffin embedded human lymphoid-dendritic cells tissue using EBI3 antibody (primary antibody at 1:200) - orb94917

Immunohistochemical staining of paraffin embedded mouse kidney tissue using Emmprin antibody (primary antibody at 1:200) - orb92689

The advantages of rat monoclonals over mouse and rabbit polyclonals

Rats have closer genetic similarity to humans meaning they will recognize a wide range of antigens and can produce IgA, IgD, IgE, IgG and IgM antibody isotypes. Their high affinity and specificity means they are an excellent choice if your target has low molecular weight or poor immunogenic properties. Rat monoclonals are highly recommended for multiple labelling experiments. If you have multiple targets to identify or quantify, you’ll find our rat mAbs will provide robust results whether used on their own or alongside other species like rabbit monoclonals and/or polyclonals. Biorbyt’s catalogue of monoclonal and polyclonal antibodies includes rabbit, rat, mouse and many other species and we are adding to our portfolio all of the time. The team at Biorbyt are here to support you to achieve reliable and accurate results. Speak to our team, we are here to provide guidance for you to reach the most effective methods for your research.

Immunohistochemical staining of paraffin embedded human placenta tissue using Integrin Beta 4 antibody (primary antibody at 1:200) - orb89149

Immunohistochemical staining of paraffin embedded mouse small intestine tissue using IL 10 antibody (primary antibody at 1:200) - orb93754

Why you should add rat mAbs to your reagent portfolio.

If you don’t already have rat mAbs in your reagent portfolio, now is the time. As well as being as stable as mouse mAbs, rat mAbs are particularly effective against small molecules and compounds and are perfect for use with mouse antigens. They can be an excellent tool when combined with other antibodies in sandwich assays. In summary, rat monoclonal antibodies offer benefits you may not have considered:

1. Closer similarity to human Fc

2. Perfect for use with mouse antigens

3. Detect poor immunogenic compounds and molecules of low molecular weight

4. High affinity

5. High sensitivity and specificity

6. No background cross-reaction problems in immune detection compared to mouse background antigens

7. Effective when used for small antigens

8. Extra epitope region

9. Versatile for multiple labelling experiments

10. Reliable and robust results

Immunofluorescence analysis of heat shocked hela cells using TCP1-alpha antibody - orb151162

Immunohistochemical staining of paraffin embedded human spleen tissue using PSGL-1 antibody (primary antibody at 1:200) - orb89237

Our Rat Monoclonal Antibodies

We work continuously to ensure that we supply the best quality products and equipment for biotechnology research. Our product portfolio is ever increasing and evolving to support our customers to achieve robust results and have confidence in the data they produce. High quality antibodies are the most essential factor to consider for any tests aimed at identifying and quantifying antigens/substances of interest. Speak to us about the specific needs of your research.