| Category | Proteins |
|---|---|
| Catalog Number | orb511247 |
| Reactivity | Rat |
| Conjugation | Unconjugated |
| MW | 105.5 kDa |
| Target | IGF-I R |
| Protein Sequence | NP_434694.1 |
| Tag | C-10×His |
| Source | Rat IGF-I R, His Tag (IGR-R5224) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - His 936 (Accession # P24062-1). |
| Biological origin | Rat |
| Storage | -20℃ |
| Purity | 90% |
| Form/Appearance | Powder |
| Buffer/Preservatives | PBS, pH7.4 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation. |
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