| Category | Proteins |
|---|---|
| Catalog Number | orb511303 |
| Reactivity | Monkey |
| Conjugation | Unconjugated |
| MW | 53.2 kDa |
| Target | LILRB4 |
| Protein Sequence | XP_015297198.1 |
| Tag | C-mFc(mIgG2a) |
| Source | Cynomolgus LILRB4, Mouse IgG2a Fc Tag (LI4-C5250) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # XP_015297198.1). |
| Biological origin | Cynomolgus |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
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