Cynomolgus IGF-I R / CD221 Protein

Catalog Number: orb511246

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Catalog Numberorb511246
MW104.9 kDa
TargetIGF-I R
Protein SequenceXP_005560632.1
SourceCynomolgus IGF-I R, His Tag (IGR-C5225) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Asn 932 (Accession # G7P9I7-1).
Biological originCynomolgus
Buffer/PreservativesPBS, pH7.4
Endotoxin1.0 EU per μg
NoteFor research use only.
Expiration Date6 months from date of receipt.
DescriptionThe Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13. and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation. There is a 60% homology between IGF1R and the insulin receptor. In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains. This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.