Cynomolgus CD38 Protein

Catalog Number: orb511245

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Catalog Numberorb511245
MW31.8 kDa
Protein SequenceNP_001274206.1
SourceCynomolgus CD38, His Tag (CD8-C5223) is expressed from human 293 cells (HEK293). It contains AA Leu 44 - Ile 301 (Accession # Q5VAN0-1).
Biological originCynomolgus
Buffer/Preservatives50 mM MES, 100 mM NaCl, pH6.5
Endotoxin1.0 EU per μg
NoteFor research use only.
Expiration Date6 months from date of receipt.
DescriptionCD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.