| Category | Proteins |
|---|---|
| Catalog Number | orb511245 |
| Reactivity | Monkey |
| Conjugation | Unconjugated |
| MW | 31.8 kDa |
| Target | CD38 |
| Protein Sequence | NP_001274206.1 |
| Tag | C-10×His |
| Source | Cynomolgus CD38, His Tag (CD8-C5223) is expressed from human 293 cells (HEK293). It contains AA Leu 44 - Ile 301 (Accession # Q5VAN0-1). |
| Biological origin | Cynomolgus |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | 50 mM MES, 100 mM NaCl, pH6.5 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia. |
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