| Category | Proteins |
|---|---|
| Catalog Number | orb511255 |
| Reactivity | Monkey |
| Conjugation | Unconjugated |
| MW | 28.4 kDa |
| Target | B7-H6 |
| Protein Sequence | XP_005578557.1 |
| Tag | C-10×His |
| Source | Cynomolgus B7-H6 Protein, His Tag (B76-C52Ha) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Asp 259 (Accession # XP_005578557.1). |
| Biological origin | Cynomolgus |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | PBS, pH7.4 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues. |
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