Cynomolgus B7-H6 / NCR3LG1 Protein

Catalog Number: orb511255

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Catalog Numberorb511255
MW28.4 kDa
Protein SequenceXP_005578557.1
SourceCynomolgus B7-H6 Protein, His Tag (B76-C52Ha) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Asp 259 (Accession # XP_005578557.1).
Biological originCynomolgus
Buffer/PreservativesPBS, pH7.4
Endotoxin1.0 EU per μg
NoteFor research use only.
Expiration Date6 months from date of receipt.
DescriptionThe B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.