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Catalog Number | orb2703966 |
---|---|
Category | Antibodies |
Description | Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor. |
Clonality | Monoclonal |
CAS Number | [2640981-19-5] |
Antibody Type | Biosimilar Antibody |
Conjugation | Unconjugated |
Target | Polzastobart Biosimilar(Anti-LILRB2 / ILT4 / CD85d Reference Antibody) |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |