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Catalog Number | orb1958083 |
---|---|
Category | Proteins |
Description | Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells of the central and peripheral nervous systems, the oligodendrocytes and Schwann cells, respectively. PMP2 may play a role in lipid transport protein in Schwann cells. It forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. |
Tag | N-His |
Purity | 98.00% |
UniProt ID | P02689 |
MW | 16kDa (predicted); 16 kDa (reducing conditions) |
Application notes | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
Expression System | E. coli |
Biological Origin | Human |
Biological Activity | Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells of the central and peripheral nervous systems, the oligodendrocytes and Schwann cells, respectively. PMP2 may play a role in lipid transport protein in Schwann cells. It forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. |
Expression Region | A DNA sequence encoding the human PMP2 (NP_002668.1) (Ser 2-Val 132) was expressed, with a polyhistide tag at the N-terminus. Predicted N terminal: Met 1 |
Storage | -20°C |
Note | For research use only |
> 90% as determined by SDS-PAGE. | |
17.07 kDa |
≥90% as determined by SDS-PAGE | |
This protein contains the human PMP2(Met1-Val132) was fused with the N-terminal His Tag and expressed in E. coli. |
> 95% by SDS-PAGE. | |
Recombinant Human PMP2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Val132) of human PMP2 (Accession #P02689) fused with a 6��His Tag at the N-terminus. |
Greater than 95% as determined by SDS-PAGE. | |
Escherichia Coli |