Phospho-KCNQ2/3/4/5 (Thr217/Thr246/Thr223/Thr251) Antibody

• Catalog Number: orb1730631
• Category: Antibodies
• Description: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
• Species/Host: Rabbit
• Clonality: Polyclonal
• Tested applications: ELISA, IHC
• Reactivity: Human, Mouse, Rat
• Isotype: Rabbit IgG
• Immunogen: The antiserum was produced against synthesized peptide derived from human Kv7.3/KCNQ3 around the phosphorylation site of Thr246. AA range:191-240
• Dilution range: IHC: 1/50-1/100; ELISA: 1/10000
• Conjugation: Unconjugated
• Entrez: 3785, 9132, 3786, 56479
• UniProt ID: P56696, O43526, O43525, Q9NR82
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Buffer/Preservatives: Liquid in PBS containing 50% glycerol, 0.5% rAlbumin and 0.02% sodium azide, pH 7.3.
• Alternative names: KCNQ2; Potassium voltage-gated channel subfamily K
• Note: For research use only
• Expiration Date: 12 months from date of receipt.