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NKCC2 antibody

NKCC2 antibody

Catalog Number: orb152685

DispatchUsually dispatched within 2-3 weeks
$ 571.00
Catalog Numberorb152685
CategoryAntibodies
DescriptionRabbit polyclonal to NKCC2 (HRP). NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell. Transport of sodium dilutes the luminal fluid, decreasing its osmolality creating an osmotic driving force for water reabsorption in the connecting tubule and cortical collecting duct under the influence of the hormone vasopressin. NKCC2 is found on the apical surface of the thick ascending limb of the loop of Henle and is blocked by loop diuretics such as furosemide..
Species/HostRabbit
ClonalityPolyclonal
Tested applicationsIHC, WB
ReactivityHuman, Mouse, Rat
ImmunogenProduced against a synthetic peptide mapping to a segment (amino acids 33-55) of the N-terminal tail of rat NKCC2 (antibody desgination L224).
Concentration1 mg/ml
Dilution rangeWB (1:1000); IHC (1:25)
ConjugationHRP
MW160kDa
TargetNKCC2
Entrez25065
UniProt IDQ5PQV1
NCBINP_001257546.1
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Alternative namesSLC12A1 antibody, sodium potassium chloride cotran
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NoteFor research use only
Application notes1 µg/ml of SPC-401 was sufficient for detection of NKCC2 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Expiration Date12 months from date of receipt.
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