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Catalog Number | orb348808 |
---|---|
Category | Proteins |
Description | CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2. |
Reactivity | Mouse |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 36 kDa |
Target | CD3 epsilon |
Protein Sequence | Asp 23 - Asp 108 |
Source | Mouse CD3E, Fc Tag (orb348808) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 108 (Accession # P22646). |
Expression System | HEK293 |
Expression Region | Asp 23 - Asp 108 |
Endotoxins | 1.0 EU per μg |
Storage | -20℃ |
Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
Alternative names | FLJ18683,T3E,TCRE,CD3E,CD3-epsilon Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 36 kDa. The protein migrates as 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Mouse CD3 epsilon protein
Greater than 90% as determined by SDS-PAGE. | |
11.9 kDa | |
Yeast |
Greater than 90% as determined by SDS-PAGE. | |
17.3 kDa | |
E.coli |
Human | |
Recombinant | |
Unconjugated |
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