LRRK2-IN-12 is a highly potent and selective inhibitor of LRRK2, demonstrating sub-nanomolar IC₅₀ values against both wild-type and the G2019S mutant kinase. This research compound is a valuable tool for in vitro and in vivo studies investigating the role of LRRK2 in neurodegenerative pathways, including Alzheimer's disease research.