Translational Research Reagents

Working in Larger Model Animal Species

High-quality, highly validated antibodies specifically raised against large animal models bridging the gap between in vitro assays and human physiology.

In recent years, the scientific community has made substantial progress to successfully embrace the 3R’s (Replacement, Reduction, and Refinement) with respect to the numbers of animals used in basic research.

Because of this reduction, it is more critically important than ever to ensure that you select the exact right animal model when your work enters the translational phase. As research moves away from initial in vitro or standard rodent models into pre-clinical validation, large animals that are significantly more analogous to Humans in size, lifespan, physiology, anatomy, and disease states are required.

A variety of species are now coming to the fore in this translational area, including Pigs, Dogs, and Bovines, each with their own distinct physiological and genetic advantages for mimicking human pathology.

1. The Antibody Reagent Gap

One major problem facing researchers moving into larger animal models is the severe lack of availability of targeted reagents specific to these species.

Closing the Gap with Biorbyt

Historically, the vast majority of commercial antibodies have been raised strictly against the more common rodent animal model species (Mouse and Rat). Biorbyt is working to directly address this critical gap. We are now able to offer an extensive variety of highly validated antibodies targeted specifically to larger animal species.

If you cannot find the specific target and species cross-reactivity you’re looking for in the featured list below, please contact our technical support team to check our full database or search online at biorbyt.com.

2. Featured Large Animal Research Products

Browse our curated selection of high-quality, validated antibodies reactive against non-rodent model species.

Cat. Code	Antibody Target	Validated Applications
orb1216667	Ferret IL-8 Antibody	ELISA, WB
orb21972	Goat anti-Swine Haptoglobin	IP
orb98223	Mouse anti-Cardiotin	IHC-Fr, IHC-P, WB
orb98233	Mouse anti-Basal cell Cytokeratin	FACS, ICC, IHC-Fr, WB
orb98235	Mouse anti-Cytokeratin 4 / Keratin K4	FACS, ICC, WB
orb98237	Mouse anti-Cytokeratin 5 + 8 / Keratin K5 + K8	FACS, ICC, IHC-Fr, IHC-P, WB
orb98239	Mouse anti-Cytokeratin 7 / Keratin K7	FACS, ICC, IHC-Fr, WB
orb98247	Mouse anti-Cytokeratin 10 / Keratin K10	FACS, ICC, IHC-Fr, WB
orb98249	Mouse anti-Cytokeratin 10 / Keratin K10 (Alt Clone)	FACS, ICC, IHC-Fr, IHC-P, WB
orb98251	Mouse anti-Cytokeratin 10+13 / Keratin K10+K13	IHC-Fr, IHC-P, WB
orb98255	Mouse anti-Cytokeratin 14 / Keratin K14	FACS, ICC, IHC-Fr, WB
orb98259	Mouse anti-Cytokeratin 18 / Keratin K18	FACS, ICC, IHC-Fr, WB
orb98263	Mouse anti-Cytokeratin 18 / Keratin K18 (Alt Clone)	FACS, ICC, IHC-Fr, IHC-P, WB
orb98271	Mouse anti-Collagen Type IV	FACS, IHC-Fr, IHC-P, WB
orb98273	Rabbit anti-Collagen IV	ICC, IHC-Fr, IHC-P, WB
orb98274	Mouse anti-Cytokeratin 13	IHC-Fr, IHC-P, WB
orb98296	Mouse anti-Desmin	IHC-Fr, ICC, WB
orb98300	Rabbit anti-Desmin K5	IHC-Fr, IHC-P, WB
orb98335	Rat anti-Heparan Sulphate Proteoglycan	ICC, IHC-Fr, IHC-P, IP, WB
orb98339	Mouse anti-Integrin alpha 3A	ICC, IHC-Fr, WB
orb98349	Mouse anti-Integrin beta 1D	ICC, IHC-Fr, WB
orb318755	Mouse anti-Lamin A (FITC Conjugated)	FACS, ICC, IHC-Fr
orb98360	Mouse anti-Lamin A	FACS, ICC, IHC-Fr, IHC-P, WB
orb318756	Mouse anti-Lamin A and C (FITC Conjugated)	FACS, ICC, IHC-Fr
orb98362	Mouse anti-Lamin A and C	FACS, ICC, IHC-Fr, WB
orb98364	Mouse anti-Lamin B1	FACS, ICC, IHC-Fr, ELISA, WB
orb98401	Mouse anti-Neurofilament 200 kD	IHC-Fr, IHC-P, WB
orb98403	Mouse anti-Neurofilament 200 kD (Alt Clone)	ICC, IHC-Fr, IHC-P, WB
orb98405	Mouse anti-Neurofilament 200 kD (Alt Clone 2)	IHC-Fr, IHC-P, WB
orb98431	Mouse anti-Plakophilin-3	ICC, IHC-Fr, IP, WB
orb98433	Mouse anti-Plakophilin-3 (Alt Clone)	IHC-Fr, IHC-P, IP, WB
orb98440	Mouse anti-Smoothelin	ICC, IHC-Fr, IHC-P, WB
orb98455	Mouse anti-Vimentin (FITC Conjugated)	FACS, ICC, IHC-Fr
orb98456	Mouse anti-Vimentin (HRP Conjugated)	FACS, ICC, IHC-Fr
orb98457	Mouse anti-Vimentin	FACS, ICC, IHC-Fr, IHC-P, WB
orb98459	Mouse anti-Vimentin (Alt Clone)	FACS, ICC, IHC-Fr, IHC-P, WB
orb108620	Rabbit anti-Human Protein Phosphatase 1 gamma 1	IP, WB
orb109013	Mouse anti-Human Insulin	ELISA, IHC, WB
orb108667	Mouse anti-Human Calpain I, II (small subunit)	IP, EIA, WB
orb108668	Mouse anti-Human Calpain I (large subunit, p80)	IP, EIA, WB
orb108685	Mouse anti-Human SNAP	IP, EIA, WB
orb108790	Mouse anti-Human p34 cdc2 nuclear protein	ICC, IHC-P, IP, WB