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Product Overview
Product Name KRT77 & KRT76 antibody
Catalog Number orb535060
Species/Host Rabbit
Reactivity Human
Conjugation Unconjugated
Tested applications IHC-P
Immunogen Recombinant full-length human KRT76 and KRT77 proteins
Target Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI > 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. It is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It may be useful to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has high sensitivity in the recognition of epithelial cells and carcinomas.
Product Properties
Form/Appearance 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.
Note For research use only.
Isotype IgG, kappa
Clonality Monoclonal
Purity Purified Ab with BSA and Azide at 200ug/ml
MW 40-67 kDa
Clone ID KRTH/1576R + KRTL/1577R
Uniprot ID Q7Z794
Entrez 374454
Product Description

Rabbit monoclonal antibody to KRT77 & KRT76

Application Notes
Dilution Range IHC-P: 0.25-0.5 μg/ml for 30 min at RT
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