Integrin alpha-M antibody

• Catalog Number: orb348856
• Category: Antibodies
• Description: Mouse monoclonal antibody to Integrin alpha-M
• Species/Host: Mouse
• Clonality: Monoclonal
• Clone Number: 107
• Tested applications: ELISA, FC
• Reactivity: Human
• Isotype: IgG1
• Immunogen: Wild type (WT) recombinant CD11b.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: Integrin α-M
• UniProt ID: P11215
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: CD11b; CD11 antigen-like family member B; CR-3 alp
• Note: For research use only
• Application notes: The antibody binds specifically to integrin α-M, a protein subunit of the α-M- β-2 molecule, which is expressed on the surface of leukocytes. Integrin α-M is involved in the adhesive interaction between molecules of the innate immune system, and plays a role in the uptake of complement-coated particles. The monoclonal antibody 107 has a blocking activity by binding to the metal-ion-dependent-adhesion site, favouring a low affinity conformation of the antigen.
• Expiration Date: 12 months from date of receipt.

References

Li, Rui et al. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b J Immunol, 168, 1219-1225 (2002)

PubMed: 11801658