This set of triterpenoid compounds, including hederagonic acid, arjunolic acid, bayogenin, and 4-epi-hederagonic acid, exhibits moderate glycogen phosphorylase inhibitory activity with IC50 values ranging from 53 to 103 µM. These inhibitors are useful research tools for studying hepatic glucose metabolism and exploring potential pathways for managing hyperglycemia in biochemical and pharmacological studies.