α7 nAchR-JAK2-STAT3 agonist 1

• Catalog Number: orb1687725
• Category: Small Molecules
• Description: α7 nAchR-JAK2-STAT3 agonist 1
• Purity: 98.00%
• MW: 426.5
• Biological Activity: α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β and IL-1β in murine macrophages RAW264.7. α7 nAchR-JAK2-STAT3 agonist 1 was effective in inhibiting the expression of iNOS, IL-1β and IL-6 in mouse macrophages. α7 nAchR-JAK2-STAT3 agonist 1 inhibited LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 agonist 1 was able to be used to study sepsis.
• CAS Number: 2108714-20-9
• Formula: C₂₅H₃₀O₆
• SMILES: O(C(C)=O)C1=C(OC(C)=O)C=CC(CC[C@H](CCCCC2=CC=CC=C2)OC(C)=O)=C1
• Storage: -20°C
• Note: For research use only