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Human TIMP-2 Protein

Catalog Number: orb257870

DispatchUsually dispatched within 5-10 working days
$ 2,664.00
Catalog Numberorb257870
CategoryProteins
DescriptionTIMP metallopeptidase inhibitor 2 is also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family protein are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members ( TIMP1, TIMP2, TIMP3, TIMP4 ), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
ReactivityHuman
TagC-8×His
Form/AppearancePowder
Purity95%
ConjugationUnconjugated
MW22.6 kDa
TargetTIMP-2
Protein SequenceNP_003246.1
SourceHuman TIMP-2, His Tag (orb257870) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Pro 220 (Accession # NP_003246.1).
Expression SystemHEK293
Expression RegionCys 27 - Pro 220
Endotoxins1.0 EU per μg
NCBINP_003246.1
Storage-20℃
Buffer/Preservatives50 mM Tris, 150 mM NaCl, pH7.5
Alternative namesCSC-21K,TIMP2
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NoteFor research use only
Application notesThis protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.6 kDa. The protein migrates as 23-26 kDa under reducing (R) condition (SDS-PAGE).
Expiration Date6 months from date of receipt.
Human TIMP-2 Protein

SDS-PAGE analysis of Human TIMP-2 protein

  • Human TIMP-2 protein [orb245328]

    Greater than 90% as determined by SDS-PAGE.

    48.5 kDa

    E.coli

    1 mg, 100 μg, 20 μg
  • Human TIMP2 protein [orb392569]

    ELISA,  MS,  SDS-PAGE,  WB

    Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

    Human cells

    500 μg, 50 μg, 10 μg
  • Human TIMP2 protein [orb754179]

    ELISA,  WB

    Greater than 95% as determined by SDS-PAGE

    21.2 kDa

    E.Coli

    100 μg, 1 mg, 200 μg, 50 μg
  • Human TIMP-2 protein [orb223933]

    SDS-PAGE

    Unconjugated

    > 95% by SDS-PAGE and HPLC analyses.

    21.8 kDa

    E. coli

    500 μg, 100 μg, 10 μg
  • Recombinant Human TIMP-2 Protein, His Tag [orb1550369]

    > 95% by Tris-Bis PAGE, > 95% by SEC-HPLC

    KMP2120, Recombinant Human TIMP-2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Cys27-Pro220) of Human TIMP-2 fused with a His Tag at the C-terminal.

    100 μg, 500 μg
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