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Catalog Number | orb257870 |
---|---|
Category | Proteins |
Description | TIMP metallopeptidase inhibitor 2 is also known as TIMP2, which belongs to the protease inhibitor I35 (TIMP) family. This family protein are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The TIMP family encompasses four members ( TIMP1, TIMP2, TIMP3, TIMP4 ), and they inhibit most MMPs by forming non-covalent binary complex. In addition to an inhibitory role against metalloproteinases, TIMP2 has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP-2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. |
Reactivity | Human |
Tag | C-8×His |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 22.6 kDa |
Target | TIMP-2 |
Protein Sequence | NP_003246.1 |
Source | Human TIMP-2, His Tag (orb257870) is expressed from human 293 cells (HEK293). It contains AA Cys 27 - Pro 220 (Accession # NP_003246.1). |
Expression System | HEK293 |
Expression Region | Cys 27 - Pro 220 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_003246.1 |
Storage | -20℃ |
Buffer/Preservatives | 50 mM Tris, 150 mM NaCl, pH7.5 |
Alternative names | CSC-21K,TIMP2 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.6 kDa. The protein migrates as 23-26 kDa under reducing (R) condition (SDS-PAGE). |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human TIMP-2 protein
Greater than 90% as determined by SDS-PAGE. | |
48.5 kDa | |
E.coli |
ELISA, MS, SDS-PAGE, WB | |
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. | |
Human cells |
ELISA, WB | |
Greater than 95% as determined by SDS-PAGE | |
21.2 kDa | |
E.Coli |
SDS-PAGE | |
Unconjugated | |
> 95% by SDS-PAGE and HPLC analyses. | |
21.8 kDa | |
E. coli |
> 95% by Tris-Bis PAGE, > 95% by SEC-HPLC | |
KMP2120, Recombinant Human TIMP-2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Cys27-Pro220) of Human TIMP-2 fused with a His Tag at the C-terminal. |
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