| Category | Proteins |
|---|---|
| Catalog Number | orb511292 |
| Reactivity | Human |
| Conjugation | Unconjugated |
| MW | 46.8 kDa |
| Target | TIM-3 |
| Protein Sequence | NP_116171.3 |
| Tag | C-mFc(mIgG2a) |
| Source | Human TIM-3, Mouse IgG2a Fc Tag, low endotoxin (TM3-H525b) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 200 (Accession # Q8TDQ0-1). |
| Biological origin | Human |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
| Endotoxin | 0.1 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428, KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis. |
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