Human RANK / TNFRSF11A Protein

Catalog Number: orb511285

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Catalog Numberorb511285
MW47.2 kDa
Protein SequenceNP_003830.1
SourceHuman RANK, Mouse IgG2a Fc Tag, low endotoxin (RAK-H5251) is expressed from human 293 cells (HEK293). It contains AA Ile 30 - Pro 212 (Accession # Q9Y6Q6-1).
Biological originHuman
Buffer/PreservativesTris with Glycine, Arginine and NaCl, pH7.5
Endotoxin0.1 EU per μg
NoteFor research use only.
Alternative namesCD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TNFRSF11A,TRANCER,CD265 antigen,ODFROSTS,RANKLOH18CR1,NFKB activator(click to expand)
Expiration Date6 months from date of receipt.
DescriptionRANK / TNFRSF11A is a member of the tumor necrosis factor receptor family. RANK / TNFRSF11A shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Functional genomics in mice showed that RANKL (TNFSF11), a member of the TNF ligand superfamily, and RANK (TNFRSF11a), the cognate TNFR family receptor for RANKL, were essential for osteoclastogenesis in vivo. A functional interaction between RANKL, expressed by bone stromal cells of the osteoblast lineage, and RANK, expressed by osteoclast precursors of hematopoietic myeloid lineage, is necessary for osteoclast differentiation, survival, and activation.