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Human PTPRD Protein

Human PTPRD Protein

Catalog Number: orb394014

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$ 4,045.00
Catalog Numberorb394014
CategoryProteins
DescriptionReceptor-type tyrosine-protein phosphatase delta is an enzyme that is encoded by the PTPRD gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRD has been shown to interact with PTPRS and liprin-alpha-1. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported. Mutations in the PTPRD gene are associated with autism, obsessive–compulsive disorder, and breast cancer.
ReactivityHuman
TagC-10×His
Form/AppearancePowder
Purity90%
ConjugationUnconjugated
MW128.6 kDa and 11.5 kDa
TargetPTPRD
Protein SequenceNP_002830.1
SourceHuman PTPRD, His Tag (orb394014) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Glu 1265 (Accession # P23468-1).
Expression SystemHEK293
Expression RegionGlu 21 - Glu 1265
Endotoxins1.0 EU per μg
NCBINP_002830.1
Storage-20℃
Buffer/PreservativesPBS, pH7.4
Alternative namesPTPRD,R-PTP-delta
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NoteFor research use only
Application notesThis protein carries a polyhistidine tag at the C-terminus. This protein contains a furin-like convertase cleavage site, 1178-RSIR-1181, and will be processed into N and C-terminal fragment with calculated MW of 128.6 kDa and 11.5 kDa respectively. The protein migrates as 116-130 kDa and 12-14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expiration Date6 months from date of receipt.
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