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Catalog Number | orb668890 |
---|---|
Category | Proteins |
Description | Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces. |
Reactivity | Human |
Tag | C-10×His |
Form/Appearance | Powder |
Purity | 90% |
Conjugation | Unconjugated |
MW | 31.2 kDa |
Target | MUC-17 |
Protein Sequence | Arg 4131 - Leu 4390 |
Source | Human MUC-17, His Tag (orb668890) is expressed from human 293 cells (HEK293). It contains AA Arg 4131 - Leu 4390 (Accession # Q685J3-1). |
Expression System | HEK293 |
Expression Region | Arg 4131 - Leu 4390 |
Endotoxins | 1.0 EU per μg |
Storage | -20℃ |
Buffer/Preservatives | PBS, pH7.4 |
Alternative names | Mucin-17,MUC-17,MUC17,MUC-3,MUC3 Read more... |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein migrates as 20 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
Greater than 95% as determined by SDS-PAGE. | |
32.0kDa | |
Mammalian cell |
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