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Human MUC-17 Protein

Human MUC-17 Protein

Catalog Number: orb668890

DispatchUsually dispatched within 5-10 working days
$ 4,205.00
Catalog Numberorb668890
CategoryProteins
DescriptionMembrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.
ReactivityHuman
TagC-10×His
Form/AppearancePowder
Purity90%
ConjugationUnconjugated
MW31.2 kDa
TargetMUC-17
Protein SequenceArg 4131 - Leu 4390
SourceHuman MUC-17, His Tag (orb668890) is expressed from human 293 cells (HEK293). It contains AA Arg 4131 - Leu 4390 (Accession # Q685J3-1).
Expression SystemHEK293
Expression RegionArg 4131 - Leu 4390
Endotoxins1.0 EU per μg
Storage-20℃
Buffer/PreservativesPBS, pH7.4
Alternative namesMucin-17,MUC-17,MUC17,MUC-3,MUC3
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NoteFor research use only
Application notesThis protein carries a polyhistidine tag at the C-terminus. This protein was cleaved within the SEA domain between 4243 Gly and 4244 Ser, and was cleaved into N and C-terminal fragment with calculated MW of 12.6 kDa and 18.6 kDa respectively. The protein migrates as 20 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expiration Date6 months from date of receipt.
  • Human MUC17 Protein [orb1476712]

    Greater than 95% as determined by SDS-PAGE.

    32.0kDa

    Mammalian cell

    20 μg, 100 μg, 1 mg
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