Human / Cynomolgus / Rhesus macaque CD28 Protein

Catalog Number: orb511238

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Catalog Numberorb511238
MW41.6 kDa
Protein SequenceNP_006130.1
SourceHuman / Cynomolgus / Rhesus macaque CD28, Fc Tag (CD8-H525a) is expressed from human 293 cells (HEK293). It contains AA Asn 19 - Pro 152 (Accession # P10747-1).
Biological originHuman / Cynomolgus / Rhesus macaque
Buffer/PreservativesTris with Glycine, Arginine and NaCl, pH7.5
Endotoxin1.0 EU per μg
NoteFor research use only.
Expiration Date6 months from date of receipt.
DescriptionT-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.