| Category | Proteins |
|---|---|
| Catalog Number | orb511238 |
| Reactivity | Monkey |
| Conjugation | Unconjugated |
| MW | 41.6 kDa |
| Target | CD28 |
| Protein Sequence | NP_006130.1 |
| Tag | C-Fc |
| Source | Human / Cynomolgus / Rhesus macaque CD28, Fc Tag (CD8-H525a) is expressed from human 293 cells (HEK293). It contains AA Asn 19 - Pro 152 (Accession # P10747-1). |
| Biological origin | Human / Cynomolgus / Rhesus macaque |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
| Endotoxin | 1.0 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells. |
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