| Category | Proteins |
|---|---|
| Catalog Number | orb511262 |
| Reactivity | Human |
| Conjugation | Unconjugated |
| MW | 45.1 kDa |
| Target | LIGHT |
| Protein Sequence | NP 003798.2 |
| Tag | N-mFc(mIgG2a) |
| Source | Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin (LIT-H5256) is expressed from human 293 cells (HEK293). It contains AA Asp 74 - Val 240 (Accession # O43557-1). |
| Biological origin | Human |
| Storage | -20℃ |
| Purity | 95% |
| Form/Appearance | Powder |
| Buffer/Preservatives | Tris with Glycine, Arginine and NaCl, pH7.5 |
| Endotoxin | 0.1 EU per μg |
| Note | For research use only. |
| Expiration Date | 6 months from date of receipt. |
| Description | Tumor necrosis factor ligand superfamily member 14(LIGHT) is a tumor necrosis factor (TNF) superfamily ligand that regulates T cell immune responses by signaling through the herpes virus entry mediator (HVEM) and the lymphotoxin beta receptor (LTbetaR). LIGHT has emerged as a potent initiator of T cell co-stimulation signals effecting CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Constitutive expression of LIGHT leads to tissue destruction and autoimmune-like disease syndromes. |
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