Human IGF-1 protein

• Catalog Number: orb107739
• Category: Proteins
• Description: The Insulin-like Growth factors (IGFs) are mitogenic polypeptide growth factors that stimulate the proliferation and survival ofvarious cell types including muscle, bone, and cartilage tissue in vitro. The liver predominantly produces iGFs, although a varietyof tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin andrelaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin.IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I andIGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptideregions, generates mature IGFs. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids,respectively, and 3 intra-molecular disulfide bonds.
• Target: IGF-1
• Conjugation: Unconjugated
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.2.
• Purity: > 97 % by SDS-PAGE and HPLC analyses
• Protein Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMYCAPLKPAKSA
• MW: 7.7 kDa
• Tested applications: HPLC, SDS-PAGE
• Biological Origin: E.coli
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Alternative names: Human Insulin-like Growth Factor-I protein
• Note: For research use only

SDS-PAGE analysis of Human IGF-1 protein