Human GITR / TNFRSF18 Protein

Catalog Number: orb511281

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CategoryProteins
Catalog Numberorb511281
ReactivityHuman
ConjugationUnconjugated
MW41.4 kDa
TargetGITR
Protein SequenceNP_004186.1
TagC-mFc(mIgG2a)
SourceHuman GITR Protein, Mouse IgG2a Fc Tag (GIR-H525a) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).
Biological originHuman
Storage-20℃
Purity95%
Form/AppearancePowder
Buffer/PreservativesTris with Glycine, Arginine and NaCl, pH7.5
Endotoxin0.1 EU per μg
NoteFor research use only.
Expiration Date6 months from date of receipt.
DescriptionGlucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.