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Catalog Number | orb257295 |
---|---|
Category | Proteins |
Description | Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. |
Reactivity | Human |
Tag | C-Fc |
Form/Appearance | Powder |
Purity | 95% |
Conjugation | Unconjugated |
MW | 40.4 kDa |
Target | CD47 |
Protein Sequence | NP_942088 |
Source | Human CD47, Fc Tag (orb257295) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # NP_942088). |
Expression System | HEK293 |
Expression Region | Gln 19 - Pro 139 |
Endotoxins | 1.0 EU per μg |
NCBI | NP_942088 |
Storage | -20℃ |
Buffer/Preservatives | 50 mM Tris, 100 mM Glycine, pH7.5 |
Alternative names | CD47,MER6,IAP,OA3 Read more... |
Note | For research use only |
Application notes | This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.4 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
SDS-PAGE analysis of Human CD47 protein
Line graph illustrates about the sensitivity range of Human CD47 protein using different concentrations
Unconjugated | |
95% | |
38.5 kDa | |
Human SIRP alpha, His Tag (orb257842) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 370 (Accession # NP_001035111). |
Unconjugated | |
95% | |
63.9 kDa | |
Human SIRP alpha, Fc Tag (orb257843) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 370 (Accession # NP_001035111). |
Unconjugated | |
95% | |
63.0 kDa | |
Human SIRP alpha, Mouse IgG1 Fc Tag (orb257844) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 370 (Accession # NP_001035111). |
Unconjugated | |
95% | |
15.6 kDa | |
Human CD47, His Tag (orb257293) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # NP_942088). |
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