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Human CD3 epsilon Protein

Catalog Number: orb257326

DispatchUsually dispatched within 5-10 working days
$ 3,885.00
Catalog Numberorb257326
CategoryProteins
DescriptionCD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
ReactivityHuman
TagC-10×His
Form/AppearancePowder
Purity90%
ConjugationUnconjugated
MW16.9 kDa
TargetCD3 epsilon
Protein SequenceNP_000724.1
SourceHuman CD3 epsilon, His Tag (orb257326) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # P07766-1).
Expression SystemHEK293
Expression RegionAsp 23 - Asp 126
Endotoxins1.0 EU per μg
NCBINP_000724.1
Storage-20℃
Buffer/PreservativesPBS, pH7.4
Alternative namesFLJ18683,T3E,TCRE,CD3E,CD3-epsilon
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NoteFor research use only
Application notesThis protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.9 kDa. Maybe caused by unknown PTMs, the protein migrates as 20-21 kDa under reducing (R) condition, and 35-45 kDa under non-reducing (NR) condition (SDS-PAGE).
Expiration Date6 months from date of receipt.
Human CD3 epsilon Protein

SDS-PAGE analysis of Human CD3 epsilon protein

Human CD3 epsilon Protein

Immobilized Anti Human CD3 MAb, mouse IgG1 at 2 ug/mL (100 uL/well) can bind Human CD3E, His Tag with a linear range of 0.4-6.25 ng/mL.

  • Human CD3 epsilon Protein [orb348813]

    Unconjugated

    95%

    39.2 kDa (CD3E) & 38.6 kDa (CD3G)

    Human CD3E&CD3G Heterodimer Protein, Fc,His Tag&Fc,Flag Tag (orb348813) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (CD3E) & Gln 23 - Ser 116 (CD3G) (Accession # P07766-1 (CD3E) & P09693-1 (CD3G)).

    50 μg, 1 mg
  • Human CD3 epsilon Protein [orb257328]

    Unconjugated

    95%

    39.2 kDa

    Human CD3 epsilon, Fc,His Tag (orb257328) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 126 (Accession # NP_000724.1).

    1 mg, 100 μg
  • Human CD3E protein [orb603969]

    Greater than 90% as determined by SDS-PAGE.

    47.7 kDa

    E.coli

    100 μg, 20 μg, 1 mg
  • Human CD3E protein [orb603968]

    Greater than 90% as determined by SDS-PAGE.

    15.8 kDa

    E.coli

    20 μg, 100 μg, 1 mg
  • Human CD3E protein [orb383281]

    Greater than 90% as determined by SDS-PAGE.

    13.8 kDa

    Yeast

    20 μg, 100 μg, 500 μg, 1 mg
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