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Human BACE-1 Protein

Catalog Number: orb257212

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$ 1,471.00
Catalog Numberorb257212
CategoryProteins
DescriptionBeta-secretase 1 (BACE1) is also known as beta-site APP cleaving enzyme 1 (beta-site amyloid precursor protein cleaving enzyme 1), memapsin-2 (membrane-associated aspartic protease 2), and aspartyl protease 2 (ASP2), β-Secretase , and is a member of the peptidase A1 protein family, BACE1 is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. BACE1 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein contains two active site aspartate residues in its extracellular protein domain and may function as a dimer. This protease is responsible for the proteolytic processing of the amyloid precursor protein (APP). Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the APP. Extracellular cleavage of APP by BACE creates a soluble extracellular fragment and a cell membrane-bound fragment referred to as C99. The elevation of BACE1 levels can be induced by amyloid plaques surrounding neurons at early stages of pathology before neuron death occurs, and may drive a positive-feedback loop in AD.
ReactivityHuman
TagC-Fc
Form/AppearancePowder
Purity90%
ConjugationUnconjugated
MW75.2 kDa & 72.6 kDa
TargetBACE-1
Protein SequenceNP_036236.1
SourceHuman BACE-1, Fc Tag (orb257212) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Thr 457 (Accession # NP_036236.1).
Expression SystemHEK293
Expression RegionThr 22 - Thr 457
Endotoxins1.0 EU per μg
NCBINP_036236.1
Storage-20℃
Buffer/Preservatives50 mM Tris, 100 mM Glycine, pH7.5
Alternative namesBACE1,ASP2,BACE,FLJ90568,HSPC104,KIAA1149,Memapsin
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NoteFor research use only
Application notesThis protein carries a human IgG1 Fc tag at the C-terminus. The Human BACE-1 will be further processed into mature form (Glu 46-Thr 457). The protein has a calculated MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form). The protein migrates as 80-96 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Expiration Date6 months from date of receipt.
Human BACE-1 Protein

SDS-PAGE analysis of Human BACE-1 protein

  • Human BACE-1 Protein [orb257210]

    Unconjugated

    98%

    49.0 kDa

    Human BACE-1, Tag Free (orb257210) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Thr 457 (Accession # NP_036236.1).

    1 mg, 100 μg
  • Human BACE-1 Protein [orb257211]

    Unconjugated

    95%

    49.3 kDa

    Human BACE-1, His Tag (orb257211) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Thr 457 (Accession # NP_036236.1).

    1 mg, 100 μg
  • Human BACE1 protein [orb753334]

    ELISA,  WB

    Greater than 95% by SDS-PAGE gel analyses

    32.5 KDa

    E.Coli

    100 μg, 1 mg, 200 μg, 50 μg
  • Human BECN1 protein [orb753341]

    ELISA,  WB

    Greater than 95% by SDS-PAGE gel analyses

    32.5 KDa

    E.Coli

    100 μg, 1 mg, 200 μg, 50 μg
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