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Product Overview
Product Name Human AGO2 Partial protein
Catalog Number orb244993
Tested applicationsSDS-PAGE
Target AGO2
Alternative Names
Product Properties
Form/Appearance Tris-based buffer, 50% glycerol
Storage Store at -20°C. for extended storage, conserve at -20°C or -80°C.
Note For research use only.
Purity >90% as determined by SDS-PAGE.
MW 38.1 kDa
Source E. coli
Biological Origin E.coli
Uniprot ID Q9UKV8
Product Description

AGO2 is required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2.

Application Notes
Application Notes This is His-tag Partial protein.
Validation Images
SDS-PAGE analysis of using Human AGO2 protein.
SDS-PAGE analysis of using Human AGO2 protein.
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