Etamicastat hydrochloride

SKU: orb1709730

Description

Etamicastat hydrochloride

Research Area

Metabolism Research

Key Properties

• CAS Number: 677773-32-9
• MW: 347.81
• Purity: 99.48%
• Formula: C₁₄H₁₆ClF₂N₃OS
• SMILES: Cl.NCCc1c[nH]c(=S)n1[C@H]1COc2c(F)cc(F)cc2C1
• Target: Hydroxylase,Dehydrogenase
• Solubility: DMSO:90 mg/mL (258.76 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.49 mM);H2O:15 mg/mL (43.13 mM)

Bioactivity

• Target IC50:
  DBH:107 nM
• In Vivo:
  Etamicastat hydrochloride (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat hydrochloride (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.
• In Vitro:
  Etamicastat hydrochloride blocks the hERG current amplitude with an IC50 value of 44 μg/mL .
• Cell Research:
  Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL .
• Animal Research:
  Etamicastat (50 mg/kg; a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DBH, BIA 5-453 Hydrochloride, BIA 5-453 hydrochloride, Etamicastat Hydrochloride

Compound Identifiers

PubChem CID

10450386