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Estrogen Receptor beta Antibody

Estrogen Receptor beta Antibody

Catalog Number: orb639642

DispatchUsually dispatched within 5-10 working days
$ 764.00
Catalog Numberorb639642
CategoryAntibodies
DescriptionEstrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Species/HostMouse
ClonalityMonoclonal
Clone NumberESR2/3005
Tested applicationsELISA
ReactivityHuman
IsotypeMouse IgG2c, kappa
ImmunogenRecombinant full-length human protein was used as the immunogen for the Estrogen Receptor beta antibody.
Dilution rangeELISA (order BSA-free format for coating)
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis Estrogen Receptor beta antibody is available for research use only.
UniProt IDQ92731
StorageStore the Estrogen Receptor beta antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
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