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Product Overview
Product Name DABCYL-TNF-a-EDANS (-4 to +6) peptide
Catalog Number orb104358
ReactivityHuman
ConjugationUnconjugated
Tested applicationsHPLC
Target DABCYL-TNF-a-EDANS (-4 to +6)
Product Properties
Storage Aliquot and store at-20°C. Avoid repeated freeze/thaw cycles.
Note For research use only.
Protein Sequence DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
Purity Greater than 98 % purified
Formula C70H104N22O18S1
MW 1573.8 Da
Product Description

TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.

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