Cyclo(RGDfC) TFA

• Catalog Number: orb1981389
• Category: Small Molecules
• Description: Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies.
• Purity: 98.59%
• MW: 692.67
• Biological Activity: Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA (Cyclo RGDfC) TFA, a cyclic RGD peptide, displays a high affinity for αvβ3 integrin, effectively disrupting cell-integrin interactions. It suppresses pluripotent marker expression in embryonic stem cells (ESCs) and reduces the tumorigenic capability of mESCs in vivo, making it valuable in tumor research [1].
• Formula: C₂₆H₃₅F₃N₈O₉S
• SMILES: O=C([C@@H](NC(CNC([C@@H](NC([C@@H](NC1=O)CS)=O)CCCNC(N)=N)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2.OC(C(F)(F)F)=O
• Storage: -20°C
• Note: For research use only