COVID-19 & SARS-CoV S glycoprotein antibody

• Catalog Number: orb758975
• Category: Antibodies
• Description: Human monoclonal antibody to COVID-19 & SARS-CoV S glycoprotein
• Species/Host: Human
• Clonality: Monoclonal
• Clone Number: CR3022
• Tested applications: ELISA, IF
• Reactivity: Virus
• Isotype: IgA1
• Immunogen: The original monoclonal antibody was generated through an scFv library derived from a peripheral blood lymphocytes of a patient exposed to the SARS-CoV.
• Concentration: 1 mg/ml
• Purity: Purified
• Conjugation: Unconjugated
• Target: COVID-19 & SARS-CoV S glycoprotein
• UniProt ID: P59594
• Storage: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
• Buffer/Preservatives: PBS with 0.02% Proclin 300.
• Alternative names: Spike protein, COVID19, COVID 19, S protein, SARS-
• Note: For research use only
• Application notes: This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune-responses to virus exposure. Human IgG1, IgG3, IgM and IgA isotypes are available to mimic antibody responses seen in COVID19 (Amanat et al. 2020). Human IgG2 and IgG4 subtypes, which are also seen in a small subset of COVID-19 patients, are also available to investigate their role in the response to SARS-CoV-2. The original human IgG1 version of the antibody works synergistically in combination with another non-ompeting SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody has been attributed a potential to be developed as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020). Bates et al. 2021 (PMID: 32766589) used CR3022 in a immunofluorescence assay.
• Expiration Date: 12 months from date of receipt.