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Product Overview
Product Name Cediranib
Catalog Number orb61177
ConjugationUnconjugated
Tested applicationsHPLC, NMR
Target Cediranib
Alternative Names
Product Properties
Storage 2 years -20 °C as powder
2 weeks 4 °C in DMSO
6 months -80 °C in DMSO
Note For research use only.
Purity >99% pure
Formula C25H27FN4O3
MW 450.514 g/mol
CAS Number [288383-20-0]
Chemical Name 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
PubChem CID CID 9933475
Product Description

Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. Cediranib is currently being evaluated in a phase II clinical trial for the treatment of advanced solid tumors.

Application Notes
Application Notes In vitro: Cediranib inhibits VEGF-stimulated proliferation with IC50 of 0.4 nM.Cediranib suppresses PDGF-AA with IC50 of 0.04 μM in MG63 cell lines.Cediranib has been shown to block Flt1-associated kinase with IC50 of 5 nM and VEGF-C and VEGF-D receptor Flt-4 with IC50 less than 3 nM.In addition, the IC50 values for inhibition of c-Kit and PDGFRβ tyrosine kinase are 2 nM and 5 nM respectively.Furthermore, no inhibition of enzyme activity is observed when 10 μM Cediranib is assayed with 100 μM ATP against AMPK, Chk1 Akt/PKB and others.Micromolar concentrations of Cediranib are needed to prevent tumor cell proliferation in vitro.

In vivo: Cediranib even suppresses tubule sprouting at subnanomolar concentrations and inhibits VEGF-induced angiogenesis.Cediranib causes hypertrophy in bone growth plate and prevents luteal development in ovary.These are physiological processes that are dependent upon angiogenesis.Cediranib shows broad spectrum activity in human tumor models at doses that are well tolerated.Besides, Cediranib causes regression of vascular tissues in human lung tumor xenografts.
Solubility (25°C)
In vitro
DMSO90 mg/mL
AlcoholEthanol (>1 mg/mL)
Water1 mg/mL
Validation Images
Cediranib (AZD2171) Chemical Structure
Cediranib (AZD2171) Chemical Structure
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