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CD18 antibody

Catalog Number: orb154416

DispatchUsually dispatched within 5-10 working days weeks.
$ 275.00
Catalog Numberorb154416
CategoryAntibodies
DescriptionMouse monoclonal antibody to CD18 which belongs to the integrin beta chain family. Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1). CD18 is involved in cellular adhesion and the immune response. CD18 and the a subunits are expressed broadly by all leukocytes with NK and T cells showing higher density of surface expression.
Species/HostMouse
ClonalityMonoclonal
Clone NumberMEM-48
Tested applicationsFA, FC, IHC-Fr, IHC-P, IP, WB
ReactivityHuman
IsotypeMouse IgG1
ImmunogenLeukocytes of a patient suffering from a LGL-type leukemia.
Concentration1 mg/ml
Dilution rangeFunctional application: The antibody MEM-48 induces high-affinity conformation of LFA-1 complex.
Western blotting: Recommended dilution: 2 μg/ml; positive control: Kg-1a human leukemia cell lysate, non-reducing conditions.
Flow cytometry: Recommended dilution: 2 μg/ml.
Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/ml; positive tissue: spleen, microglia.
PurityPurified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
ConjugationUnconjugated
TargetCD18
Entrez3689
UniProt IDP05107
StorageStore at 2-8°C. Do not freeze.
Buffer/PreservativesPhosphate buffered saline (PBS), pH 7.4
Alternative namesAnti-Integrin beta2 antibody, anti-Complement rece
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NoteFor research use only
Application notesLow Endotoxin, Azide free format. Product does not contain preservatives and is intended primarily for functional applications. Preservative containing buffers are available for IHC applications
Expiration Date12 months from date of receipt.
CD18 antibody

Separation of human leukocytes (red-filled) from CD18 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD18 (MEM-48) purified antibody (concentration in sample 1 μg/ml, GAM APC).

CD18 antibody

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD18 (MEM-48) purified antibody (concentration in sample 1 μg/ml, GAM APC).

CD18 antibody

Immunohistochemistry staining of human spleen (paraffin sections) using anti-CD18 (MEM-48).

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